After a false alarm, HP is keeping to its initial promise of delivering its Slate 7 Android tablet this month -- and with a few days to spare, no less. The seven-inch device, which first popped up at MWC back in February, is now on sale in the US through the company's retail site, for the low, low price of $170. Click on the source link below to get your hands on the Beats-rocking Nexus 7 competitor.
It?s no surprise that banks and financial sectors are the institutions least trusted by U.S. society. Trust reached an all-time low of 24 percent in 2011, down from 69 percent in 2008. In an effort to rebuild confidence in financial institutions, Congress enacted two financial reform bills (Sarbanes Oxley in 2002 and Dodd-Frank in 2012). These efforts, however, have not sufficed.
To rebuild trust, investors and the public need comparable data on how financial institutions are managing environmental, social and governance (ESG) performance. Enter SASB.
In February, we convened a group of 300 people ? representing $5 trillion in assets under management and $1.3 trillion in market capital ? to participate in working groups to help establish sustainability accounting standards for the financials sector. They weighed in on sustainability accounting standards for the disclosure of material ESG issues for seven industries, including commercial banks, mortgage finance and insurance.
SASB research revealed that the core impact of the Financials sector on economic development underpins ESG issues for the sector. With great power comes great responsibility ? this sector has power to fuel tremendous growth while also potentially creating negative externalities for society and the environment. For example, the consumer finance industry creates positive societal value via financial flexibility for low-income populations. But it also creates negative externalities ? as of September 2012 the total credit card debt in the U.S. stood at $852 billion, 5 percent of the national debt that same year and just shy of the entire GDP of Taiwan for the same year.
There are other examples of how the Financials sector, when at its best, can bring great benefit to society. A 2012 study by the American Council for an Energy-Efficient Economy found that energy efficiency, which can be promoted in part by mortgage products, could save consumers an average of $2,600 ? that's $400 billion in all, per year ? while also presenting a considerable opportunity for mortgage finance companies.
The social license to operate enjoyed by the financials sector can be traced back to ancient times, when temples commonly served as banks. Governance issues, determined by SASB research to be among the most material of ESG issues for the sector, have the potential to shake public trust in the near-sacred institutions in this sector. Governance is made particularly complicated by the concentration of large players intertwined in multiple roles. Banks, for example, are often on several sides of the same transaction ? as principal investor, advisor and provider of debt financing. This leads to potential conflict of interest, systemic risk and regulatory compliance.
The SASB research team is evaluating the feedback the Financials working groups provided on our draft sustainability accounting standards. On May 1, the standards were released for a 30-day public comment period.
SASB rapidly is gaining momentum. Our Financials working groups were three times the size of our working groups for our first sector, Health Care. Over 200 people attended our groundbreaking Delta Series Conference in NY. It brought securities lawyers and sustainability professionals to the table together ? possibly for the first time ? to discuss materiality in terms of the U.S. securities law and the SEC, as well as the intersection of CSR and the Form 10-K.
Next up, we begin our working groups for Technology & Communications in May, followed by non-renewables in August. SASB is using rapid prototyping to produce a full set of standards for 88 industries in just 2.5 years.
In order to maintain our steep trajectory to quickly produce standards, we need your help. Participate in our period of public comment on draft Financials sector standards from May 1 to May 30. Sign up by May 6 for our Technology & Communications industry working group. Register for our new webinar series that launches soon. Together, we can set standards that will spark real action and innovation ? for the benefit of companies, investors and society.
The agreement to 'normalize' relations between Serbia and Kosovo, which declared independence from Serbia five years ago, removes a major obstacle to each one's bid to join the EU.
By Andrew MacDowall,?Correspondent / April 25, 2013
Members of the Serbian government attend a session in Belgrade, Serbia, on Monday. The Serbian government approved a potentially landmark agreement to normalize relations with breakaway Kosovo that could end years of tensions and put the Balkan rivals on a path to European Union membership.
Marko Drobnjakovic/AP
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This week?s breakthrough deal between Serbia and the disputed territory of Kosovo moves both closer to European Union membership and a conclusion to one of Europe?s last frozen conflicts. But progress towards EU accession is still fraught with difficulty, as Europe continues to struggle with its economic crisis.
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On Monday, the European Commission, the EU?s executive body, recommended that Brussels start formal negotiations on Serbian accession, after the Serbian government agreed to sign a draft agreement ?normalizing? relations with Kosovo, which it still refuses to recognize.
Kosovo unilaterally declared independence in 2008, nine years after a NATO bombing campaign led to Serbian withdrawal from most of the territory, which the majority of Serbs see as part of their country. The deal allows the ethnic-Albanian-dominated government in Pristina to control all of Kosovo, including the predominantly Serbian north.
?This is not recognition, but it is a big step towards it,? says James Ker-Lindsay, senior research fellow on South East European politics at the London School of Economics. ?You can take the view that the agreement still allows Serbia to maintain the fiction that Kosovo is a province of Serbia, just ruled from Pristina. But eventual acceptance of Kosovo is where Serbia is going with all this.?
'A big step'
The deal came after months of on-off negotiations brokered by the EU. Belgrade agreed to sign after Kosovo made concessions on policing of the north, and on a clause which now states that the two countries must not try to block each other?s EU accession process. The revised wording ? which previously referred to membership of any international institutions ? allows Serbia to continue its opposition to Kosovo joining the UN, a related but separate diplomatic battle that had been a sticking point in the EU talks.
Pristina?s reward for this ? other than the de facto recognition of its sovereignty over the whole territory ? will be a Stabilisation and Association Agreement (SAA) with the EU, considered the first step towards membership.
For Serbia, the prospect of EU talks has particular political, diplomatic, and economic significance. It indicates that the country, considered an international pariah less than 15 years ago, is increasingly being accepted back into the international mainstream.
The fact that the Kosovo deal was signed by a coalition of nationalists and socialists which was decried last year for its far-right past and links to late strongman president Slobodan Milosevic has a Nixon-to-China element to it; an EU deal may boost the government?s standing further before possible snap elections in the autumn.
And for the beleaguered Serbian economy, which re-entered recession last year, concrete steps towards the EU should provide a boost in terms of greater stability, impetus for reform, and future funding.
A long way to go
However, accession is far from an easy process, or a short one. Serbia is not likely to join before the next decade, after painstaking economic, judicial, and administrative restructuring. Serbia?s unhappy recent past ? and the EU's experience of integrating Romania and Bulgaria ? mean that Brussels is likely to be particularly stringent in ensuring that the country meets its standards.
As Dr. Ker-Lindsay points out, it is not even certain that negotiations will start any time soon.
?There is a real possibility that Germany or other countries will say that this is still not good enough, which would have a very harmful effect, and lead to a sense of betrayal in Serbia,? he says.
With the EU faced with record levels of skepticism among its own citizens, and its economies struggling to recover from prolonged crisis, Serbian accession may not seem a priority; it is hardly a vote-winner with EU electorates. And it remains to be seen what sort of EU Serbia would be joining ? in a decade?s time it could be a rather different organization.
But for all the necessary caveats, this week?s agreement could prove a landmark in resolving conflicts in a troubled region.
Contact: Dr. Panayotis Dimopoulos Panayotis.Dimopoulos@empa.ch 41-587-654-337 Swiss Federal Laboratories for Materials Science and Technology (EMPA)
Novel gas catalysts
Conventional catalytic cleaning units for exhaust gases are made with a regular honeycomb structure. The catalytically active layer, which contains valuable noble metals such as platinum, rhodium or palladium, is deposited on the surface of this one-piece, or monolithic, ceramic substrate. The hot exhaust gases flow through the catalyst in a non-turbulent manner. However, since most of the flow occurs in the middle of the catalyst, this region becomes exhausted more rapidly than the peripheral areas of the monolith, which remain more or less unused. In order to extend the service life of the unit, it must be made longer. But longer also means more surface area, more noble metal content and therefore higher cost.
Efficiency originating at Empa
Empa researchers from the Internal Combustion Engines Laboratory, under the leadership of Panayotis Dimopoulos Eggenschwiler, have succeeded in finding an innovative solution to this problem. The team is working on a catalytic substrate made of ceramic foam which, in future, will replace the conventional monolithic structure. For the same catalytic performance the novel device is significantly cheaper than the monolith-based unit. In contrast to the latter, the ceramic foam has in an irregular structure much like a sponge which causes the gas passing through it to flow in a turbulent manner, distributed equally throughout the whole of its volume. Although the foam catalyst actually has less surface area than the monolith, this area is much more efficiently utilized. As a result, to achieve the same effect as a conventional catalytic unit, the ceramic type requires only one third as much expensive noble metal and only half the physical length.
Despite the fragility of the ceramic foam, with the help of colleagues from Empa's High-Performance Ceramics Laboratory the scientists succeeded in increasing the mechanical strength of the material many times over. Currently the research team is working to optimize the structure of the ceramic the foam substrate has a greater air resistance than the monolith, which results in a slight comparative increase in fuel consumption. Using sophisticated computer simulation techniques, the Empa team has developed foam structures which reduce the air resistance without affecting the necessary turbulence.
Although at the moment the foam catalyst is being manufactured purely on the laboratory scale at Empa, industrial contacts are already showing interest in the new device. The Belgian material technologies company Umicore is a partner in the project, as is Fiat Powertrain Technologies. The foam catalyst is being proven in a diesel test vehicle on the Empa site. In addition, over the last 18 months a vehicle fitted with the innovative new catalyst belonging to the Industriellen Werke Basel (IWB) has been driven around in a long-term test eventually intended to cover at least 150,000 km.
Cheaper catalysts despite more stringent exhaust gas standards
The Foamcat represents the ideal alternative to the monolithic catalyst, above all for small diesel vehicles. After the Euro 6 exhaust-gas standard comes into force in September 2014, polluting emissions from diesel motors will be obliged to sink significantly. In particular, after this date a nitrogen monoxide catalyst will be compulsory. In combination with a particle filter and the conventional hydrocarbon and carbon dioxide catalyst, this will make exhaust gas treatment for diesel automobiles significantly more expensive. With its greatly reduced requirement of expensive noble metals, Empa's Foamcat will help to minimize these costs.
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Contact: Dr. Panayotis Dimopoulos Panayotis.Dimopoulos@empa.ch 41-587-654-337 Swiss Federal Laboratories for Materials Science and Technology (EMPA)
Novel gas catalysts
Conventional catalytic cleaning units for exhaust gases are made with a regular honeycomb structure. The catalytically active layer, which contains valuable noble metals such as platinum, rhodium or palladium, is deposited on the surface of this one-piece, or monolithic, ceramic substrate. The hot exhaust gases flow through the catalyst in a non-turbulent manner. However, since most of the flow occurs in the middle of the catalyst, this region becomes exhausted more rapidly than the peripheral areas of the monolith, which remain more or less unused. In order to extend the service life of the unit, it must be made longer. But longer also means more surface area, more noble metal content and therefore higher cost.
Efficiency originating at Empa
Empa researchers from the Internal Combustion Engines Laboratory, under the leadership of Panayotis Dimopoulos Eggenschwiler, have succeeded in finding an innovative solution to this problem. The team is working on a catalytic substrate made of ceramic foam which, in future, will replace the conventional monolithic structure. For the same catalytic performance the novel device is significantly cheaper than the monolith-based unit. In contrast to the latter, the ceramic foam has in an irregular structure much like a sponge which causes the gas passing through it to flow in a turbulent manner, distributed equally throughout the whole of its volume. Although the foam catalyst actually has less surface area than the monolith, this area is much more efficiently utilized. As a result, to achieve the same effect as a conventional catalytic unit, the ceramic type requires only one third as much expensive noble metal and only half the physical length.
Despite the fragility of the ceramic foam, with the help of colleagues from Empa's High-Performance Ceramics Laboratory the scientists succeeded in increasing the mechanical strength of the material many times over. Currently the research team is working to optimize the structure of the ceramic the foam substrate has a greater air resistance than the monolith, which results in a slight comparative increase in fuel consumption. Using sophisticated computer simulation techniques, the Empa team has developed foam structures which reduce the air resistance without affecting the necessary turbulence.
Although at the moment the foam catalyst is being manufactured purely on the laboratory scale at Empa, industrial contacts are already showing interest in the new device. The Belgian material technologies company Umicore is a partner in the project, as is Fiat Powertrain Technologies. The foam catalyst is being proven in a diesel test vehicle on the Empa site. In addition, over the last 18 months a vehicle fitted with the innovative new catalyst belonging to the Industriellen Werke Basel (IWB) has been driven around in a long-term test eventually intended to cover at least 150,000 km.
Cheaper catalysts despite more stringent exhaust gas standards
The Foamcat represents the ideal alternative to the monolithic catalyst, above all for small diesel vehicles. After the Euro 6 exhaust-gas standard comes into force in September 2014, polluting emissions from diesel motors will be obliged to sink significantly. In particular, after this date a nitrogen monoxide catalyst will be compulsory. In combination with a particle filter and the conventional hydrocarbon and carbon dioxide catalyst, this will make exhaust gas treatment for diesel automobiles significantly more expensive. With its greatly reduced requirement of expensive noble metals, Empa's Foamcat will help to minimize these costs.
###
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Cabinet glass styles reflect the nuance of the house. Typically, it?s intentionally put in the living room to be the center of attention, besides it?s used as the storage media for certain things. The host collections such as chinaware and ornamentals are usually the things that are put within the cabinet glass. Transparency of glass is the reason why people like to keep the things they want to show off to the others. No wonder, it?s placed in the living room to welcome the guests.
Ordinary glass cabinets are usually designed incorporate with the carving touching and leaving the impression of rigid, but nowadays, cabinet glass styles are present with the contemporary models and designs to rejuvenate and refresh the atmosphere in your nice living room. The concept of contemporary which emphasizes to the simplicity and flexibility of its model will enable the host to match it with other furniture. Besides, this kind of cabinet glass styles will not take much spaces of your living room as ordinary or common cabinet glass all this time, but it depends on the needs and the interests of the people themselves respectively. However, the option of contemporary styles of cabinet glass to be implemented in your living room is still being smart choice.
These days, the sentiment of anyone who doesn't know how to code being destined to a life of homeless ineptitude has become a fairly common (if mildly exaggerated) one. But of all the ways out there to save yourself from a derelict fate, Jon Duckett's HTML and CSS: Design and Buil Websites, is, perhaps, the most beautiful, information-packed intro to basic web languages you can find. More »
FRANKFURT, Germany (AP) ? Daimler AG warned Wednesday that profits this year would be lower than last year's as it reported a 60 percent slide in first-quarter earnings amid slumping auto sales in Europe.
The maker of Mercedes-Benz luxury cars said net profit fell to 564 million euros ($733 million) from 1.42 billion euros in the same quarter a year ago. Revenue was down 3 percent at 26.1 billion euros.
Profits fell short of the 810 million euros expected by analysts surveyed by financial information provider FactSet. The company's share price was steady at ?40.90 in morning trading in Europe.
Daimler laid much of the blame on the economic problems afflicting many countries in Europe. The economy of the 17 countries that use the euro currency is in a recession and struggling to reduce excessive levels of government debt.
CEO Dieter Zetsche said "many markets developed worse than expected for economic reasons, especially in Western Europe. "
Daimler kicked off what could be a rough earnings quarter for European carmakers, as the region's sales have slumped alarmingly in the first three months of the year. U.S.-based Ford Motor Co. reports earnings later Wednesday.
European auto sales fell 9.8 percent in March, the 18 monthly drop in a row, measured on a year on year basis, according to the European car industry association ACEA. Consumers are reluctant or unable to spend, as governments cut spending to deal with their debt problems. That has dented growth rates across Europe and pushed unemployment higher.
The economic fallout is worst in indebted countries in southern Europe such as Italy and Spain. But sales have also fallen in better-off Germany, home market for Daimler's flagship Mercedes-Benz luxury brand. Sales for all auto companies fell 13 percent there in March.
Stuttgart-based Daimler said it expected the U.S. and Chinese markets to grow but warned that European car sales would decline further this year. The company said that "the German market cannot detach itself from this development and is expected to fall significantly short of the previous year's level." Daimler also said the market for trucks would fall 5 percent due to the slow economy.
The company's flagship Mercedes brand saw sales fall in the key Chinese market as it reorganized its sales operation there. High spending of 1.6 billion euros on new plants and equipment also hurt earnings for the quarter.
The company said that earnings before interest and tax for this year would come in below last year's figure of 8.1 billion euros, due to lowered market expectations and the weak first quarter performance. The company had previously said this year's earnings would match last year's.
The profit prediction was also reduced because Daimler has sold its 15 percent stake in aerospace firm EADS, parent company of plane maker Airbus. Daimler's future earnings will therefore no longer include a share of EADS profits or losses. Daimler had 22.5 percent of EADS voting rights, and so had been reporting that proportion of EADS income.
Apr. 23, 2013 ? There's big news in the world of tiny things. New research led by University of Cincinnati physics professors Howard Jackson and Leigh Smith could contribute to better ways of harnessing solar energy, more effective air quality sensors or even stronger security measures against biological weapons such as anthrax. And it all starts with something that's 1,000 times thinner than the typical human hair -- a semiconductor nanowire.
UC's Jackson, Smith, recently graduated PhD student Melodie Fickenscher and physics doctoral student Teng Shi, as well as several colleagues from across the US and around the world recently have published the research paper "Optical, Structural and Numerical Investigations of GaAs/AlGaAs Core-Multishell Nanowire Quantum Well Tubes" in Nano Letters, a journal on nanoscience and nanotechnology published by the American Chemical Society. In the paper, the team reports that they've discovered a new structure in a semiconductor nanowire with unique properties.
"This kind of structure in the gallium arsenide/aluminum gallium arsenide system had not been achieved before," Jackson says. "It's new in terms of where you find the electrons and holes, and spatially it's a new structure."
EYES ON SIZE AND CORNERING ELECTRONS
These little structures could have a big effect on a variety of technologies. Semiconductors are at the center of modern electronics. Computers, TVs and cellphones have them. They're made from the crystalline form of elements that have scientifically beneficial electrical conductivity properties. Many semiconductors are made of silicon, but in this case they are made of gallium arsenide. And while widespread use of these thin nanowires in new devices might still be around the corner, the key to making that outcome a reality in the coming years is what's in the corner.
By using a thin shell called a quantum well tube and growing it -- to about 4 nanometers thick -- around the nanowire core, the researchers found electrons within the nanowire were distributed in an unusual way in relation to the facets of the hexagonal tube. A close look at the corners of the tube's facets revealed something unexpected -- a high concentration of ground state electrons and holes.
"Having the faceting really matters. It changes the ballgame," Jackson says. "Adjusting the quantum well tube width allows you to control the energy -- which would have been expected -- but in addition we have found that there's a highly localized ground state at the corners which then can give rise to true quantum nanowires."
The nanowires the team uses for its research are grown at the Australian National University in Canberra, Australia -- one partner in this project that extends to disparate parts of the globe.
AFFECTING THE SCIENCE OF SMALL IN A BIG WAY
The team's discovery opens a new door to further study of the fundamental physics of semiconductor nanowires. As for leading to advances in technology such as photovoltaic cells, Jackson says it's too soon to tell because quantum nanowires are just now being explored. But in a world where hundreds of dollars' worth of technology is packed into a 5-by-2.5 inch iPhone, it's not hard to see how small but powerful science comes at a premium.
The team at UC is one of only about a half dozen in the US conducting competitive research in the field. It's a relatively young discipline, too, Jackson says, and one that's moving fast. For such innovative science, he says it's important to have a collaborative effort. The team includes scientists from research centers in the Midwest, the West Coast and all the way Down Under: UC, Miami University of Ohio and Sandia National Laboratories in California here in the US; and Monash University and the Australian National University in Australia.
The team's efforts are another example of how UC not only stands out as a leader in top-notch science, but also in shaping the future of the discipline by providing its students with high-quality educational and research opportunities.
"We're training students in state-of-the-art techniques on state-of-the-art materials doing state-of-the-art physics," Jackson says. "Upon completing their education here, they're positioned to go out and make contributions of their own."
Additional contributors to the paper are Jan Yarrison-Rice of Miami University, Oxford, Ohio; Bryan Wong of Sandia National Laboratories, Livermore, Calif.; Changlin Zheng, Peter Miller and Joanne Etheridge of Monash University, Victoria, Australia; and Qiang Gao, Shriniwas Deshpande, Hark Hoe Tan and Chennupati Jagadish of the Australian National University, Canberra, Australia.
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The above story is reprinted from materials provided by University of Cincinnati.
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Journal Reference:
Melodie Fickenscher, Teng Shi, Howard E. Jackson, Leigh M. Smith, Jan M. Yarrison-Rice, Changlin Zheng, Peter Miller, Joanne Etheridge, Bryan M. Wong, Qiang Gao, Shriniwas Deshpande, Hark Hoe Tan, Chennupati Jagadish. Optical, Structural, and Numerical Investigations of GaAs/AlGaAs Core?Multishell Nanowire Quantum Well Tubes. Nano Letters, 2013; 13 (3): 1016 DOI: 10.1021/nl304182j
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
By using swarms of untethered grippers, each as small as a speck of dust, Johns Hopkins engineers and physicians say they have devised a new way to perform biopsies that could provide a more effective way to access narrow conduits in the body as well as find early signs of cancer or other diseases.
In two recent peer-reviewed journal articles, the team reported successful animal testing of the tiny tools, which require no batteries, wires or tethers as they seize internal tissue samples. The devices are called "mu-grippers," incorporating the Greek letter that represents the term for "micro." Instead of relying on electric or pneumatic power, these star-shaped tools are autonomously activated by the body's heat, which causes their tiny "fingers" to close on clusters of cells. Because the tools also contain a magnetic material, they can be retrieved through an existing body opening via a magnetic catheter.
In the April print edition of Gastroenterology, the researchers described their use of the mu-grippers to collect cells from the colon and esophagus of a pig, which was selected because its intestinal tract is similar to that of humans. Earlier this year, the team members reported in the journalAdvanced Materials that they had successfully inserted the mu-grippers through the mouth and stomach of a live animal and released them in a hard-to-access place, the bile duct, from which they obtained tissue samples.
"This is the first time that anyone has used a sub-millimeter-sized device -- the size of a dust particle -- to conduct a biopsy in a live animal," said David Gracias, an associate professor of chemical and biomolecular engineering whose lab team developed the microgrippers. "That's a significant accomplishment. And because we can send the grippers in through natural orifices, it is an important advance in minimally invasive treatment and a step toward the ultimate goal of making surgical procedures noninvasive."
Another member of the research team, physician Florin M. Selaru of the Johns Hopkins School of Medicine, said the mu-grippers could lead to an entirely new approach to conducting biopsies, which are considered the "gold standard" test for diagnosing cancer and other diseases.
The advantage of the mu-grippers, he said, is that they could collect far more samples from many more locations. He pointed out that the much larger forceps used during a typical colonoscopy may remove 30 to 40 pieces of tissue to be studied for signs of cancer. But despite a doctor's best intentions, the small number of specimens makes it easy to miss diseased lesions.
"What's the likelihood of finding the needle in the haystack?" said Selaru, an assistant professor in the Division of Gastroenterology and Hepatology. "Based on a small sample, you can't always draw accurate inferences. We need to be able to do a larger statistical sampling of the tissue. That's what would give us enough statistical power to draw a conclusion, which, in essence, is what we're trying to do with the microgrippers. We could deploy hundreds or even thousands of these grippers to get more samples and a better idea of what kind of or whether a disease is present."
Although each mu-gripper can grab a much smaller tissue sample than larger biopsy tools, the researchers said each gripper can retrieve enough cells for effective microscopic inspection and genetic analysis. Armed with this information, they said, the patient's physician could be better prepared to diagnose and treat the patient.
This approach would be possible through the latest application of the Gracias lab's self-assembling tiny surgical tools, which can be activated by heat or chemicals, without relying on electrical wires, tubes, batteries or tethers. The low-cost devices are fabricated through photolithography, the same process used to make computer chips. Their fingerlike projections are made of materials that would normally curl inward, but the team adds a polymer resin to give the joints rigidity and to keep the digits from closing.
Prior to a biopsy, the grippers are kept on ice, so that the fingers remain in this extended position. An endoscopy tool then is used to insert hundreds of grippers into the area targeted for a biopsy. Within about five minutes, the warmth of the body causes the polymer coating to soften, and the fingers curl inward to grasp some tissue. A magnetic tool is then inserted to retrieve them.
Although the animal testing results are promising, the researchers said the process will require further refinement before human testing can begin. "The next step is improving how we deploy the grippers," Selaru said. "The concept is sound, but we still need to address some of the details. The other thing we need to do is thorough safety studies."
Further development can be costly, however. The team has applied for grants to fund advances in the project, which is protected by provisional patents obtained through the Johns Hopkins Technology Transfer Office. Biotechnology investors might also help move the project forward.
"It is more a question of money than time as to how long it will take before we could use this in human patients," Selaru said
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Johns Hopkins University: http://www.jhu.edu
Thanks to Johns Hopkins University for this article.
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NEW YORK (AP) -- Former congressman Anthony Weiner is back on Twitter.
The Democrat, who resigned in disgrace two years ago after tweeting a lewd picture of himself, has launched a new Twitter account: (at)anthonyweiner.
Weiner's first post Monday was decidedly tame: a link to a 20-page policy statement outlining "64 Ideas to keep New York City the Capital of the Middle Class." By late afternoon, he had a few thousand followers.
Weiner, 48, confirmed by email Monday that the new Twitter account is his.
"It seemed like a fresh start was in order especially in light of all the new ideas around which I am hoping to drive conversation and debate," he wrote.
Weiner, who is married and has a baby son, ran for mayor in 2005 and considered it in 2009. He said this month in a New York Times Magazine story that he is considering joining the race to succeed Mayor Michael Bloomberg.
An NBC New York-Marist Poll last week showed about half the Democrats surveyed wouldn't even consider voting for him because of the sexting scandal. But it also showed he'd get 15 percent of the vote in a potential Democratic primary, topped only by the current front-runner, City Council Speaker Christine Quinn. There were similar results in a Quinnipiac University poll released last week.
In the 2011 sexting scandal, Weiner initially claimed he had been hacked after a photo of a man's underwear-clad crotch appeared on his Twitter account. As more pictures surfaced, including one of Weiner posing shirtless in his congressional office, he was forced to come clean and acknowledged exchanging inappropriate messages with several women.
Weiner's old Twitter account, (at)repweiner, still has about 68,000 followers.
April 22 (Reuters) - Pep Guardiola is not the only connection between Bayern Munich and Barcelona, who meet in their Champions League semi-final, first leg at the Allianz Arena on Tuesday. Both teams are dominating their leagues to an almost embarrassing extent, have won the Champions League four times apiece, share an acrimonious rivalry with Real Madrid, and owe part of their success to the flamboyant Dutchman Louis van Gaal. Both have also been in two Champions League finals in the last four years, though the Catalans won both of theirs and the Bavarians came out losers on each occasion. ...
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Apr. 22, 2013 ? North Carolina State University researchers studying aquatic organisms called Daphnia have found that exposure to a chemical pesticide has impacts that span multiple generations -- causing the so-called "water fleas" to produce more male offspring, and causing reproductive problems in female offspring.
"This work supports the hypothesis that exposure to some environmental chemicals during sensitive periods of development can cause significant health problems for those organisms later in life -- and affect their offspring and, possibly, their offspring's offspring," says Dr. Gerald LeBlanc, a professor of environmental and molecular toxicology at NC State and lead author of a paper on the work. "We were looking at a model organism, identified an important pathway for environmental sex determination, and found that there are chemicals that can hijack that pathway."
Environmental cues normally determine the sex, male or female, of Daphnia offspring, and researchers have been working to understand the mechanisms involved. As part of that work, LeBlanc's team had previously identified a hormone called methyl farnesoate (Mf) that Daphnia produce under certain environmental conditions.
The researchers have now found that the hormone binds with a protein receptor called the Mf receptor, which can regulate gene transcription and appears to be tied to the production of male offspring.
In experiments, the researchers exposed Daphnia to varying levels of an insecticide called pyriproxyfen, which mimics the Mf hormone. The pyriproxyfen exposure resulted in Daphnia producing more male offspring and fewer offspring in total, with higher doses exacerbating both effects.
"At high concentrations, we were getting only male offspring, which is not good," LeBlanc says. "Producing fewer offspring, specifically fewer female offspring, could significantly limit population numbers for Daphnia."
And low exposure concentrations had significant impacts as well. At pyriproxyfen concentrations as low as 71 nanograms per liter, or 71 parts per trillion, the Daphnia would still produce some female offspring. But those females suffered long-term reproductive health effects, producing significantly smaller numbers of offspring -- despite the fact that they had not been exposed to pyriproxyfen since birth.
"We now want to know specifically which genes are involved in this sex determination process," LeBlanc says. "And, ecologically, it would be important to know the impact of changes in population dynamics for this species. Daphnia are a keystone species -- an important food source for juvenile fish and other organisms."
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The above story is reprinted from materials provided by North Carolina State University.
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Journal Reference:
Gerald A. LeBlanc, Ying H. Wang, Charisse N. Holmes, Gwijun Kwon, Elizabeth K. Medlock. A Transgenerational Endocrine Signaling Pathway in Crustacea. PLoS ONE, 2013; 8 (4): e61715 DOI: 10.1371/journal.pone.0061715
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
LONDON (AP) ? American midfielder Clint Dempsey tied the game in the 75th minute with the first of three Tottenham goals in a seven-minute span, and Spurs rallied past Manchester City 3-1 Sunday to move the defending Premier League champions to the brink of elimination.
Manchester United (26-4-3) can clinch a record 20th English league title when it hosts Aston Villa on Monday night. City (20-5-8), which led after Samir Nasri's fifth-minute goal, trails by 13 points and has five games remaining.
Dempsey slid to poke in Gareth Bale's cross with his left leg from 2 yards, beating goalkeeper Joe Hart. In his first season with Spurs, Dempsey has six league goals and 11 overall. Jermain Defoe put Tottenham ahead in the 79th, and Bale scored in the 82nd.
Arsenal (18-7-9) is third with 63 points, one ahead of Chelsea (18-7-8), which allowed Luis Suarez's goal in the seventh minute of second-half stoppage time in a 2-2 draw at Liverpool. Trying to finish among the top four and earn a berth in next season's Champions League, Tottenham (18-8-7) is fifth with 61.
Taiwan’s Fair Trade Commission is investigating charges that Samsung paid students to attack rival HTC’s smartphones online. The South Korean tech giant could potentially face a fine of up to NTD $25 million ($835,000 USD) if the charges of false advertising are upheld. Samsung’s Taiwanese agent allegedly hired students to write online articles attacking HTC and recommending Samsung handsets. In response, Samsung’s Taiwan office posted a note on its Facebook page apologizing for “any inconvenience and confusion” and saying it “has halted all Internet marketing such as posting articles on Web sites.” This is not the first time that Samsung has been in hot water with the Taiwanese Fair Trade Commission–back in January, it disclosed that it had been fined NTD $300,000 (about $10,389 USD) for an advertisement that featured “misleading” information about the Samsung Galaxy Y Duos GT-S6012. Samsung was charged with falsely stating in online and catalog advertisements that the phone has automatic focus and flash functions, which it doesn’t. And last fall, Toshiba Samsung Storage Technology (a joint venture of the two companies) was fined, along with several other companies, for fixing the prices of optical disc drives. If the current crop of charges against Samsung are true, the tactics seem rather heavy-handed. According to IDC, Samsung currently has a 30.3 percent chunk of the global smartphone market, while HTC holds just a 4.6 percent slice. Despite rave reviews for the HTC One and the release of the HTC First Facebook Home phone, the Taiwanese company has struggled over the past year as its sales slumped, due in large part to the delayed release of the HTC One.
NEW YORK (AP) ? A steep fall in commodity prices pulled down energy and mining stocks for a second day on Monday. The Dow Jones industrial average dropped more than 200 points, putting it on course for its worst loss since February.
Gold plunged below $1,400 an ounce for the first time in two years as a sell-off in metals continued from last week. Oil prices hit their lowest level since mid-December.
"I think you're getting some panic selling right now" in the gold market, said Frank Fantozzi, CEO of Planned Financial Services, a wealth management firm.
The Dow was down 207 points at 14,658 as of 3:14 p.m., a drop of 1.4 percent. Caterpillar, which makes heavy equipment used by miners, led the Dow lower with a drop of 3 percent to $82.67.
A report that China's economy unexpectedly slowed pummeled copper and other commodities. The world's second-largest economy expanded by 7.7 percent in the first three months of the year, well below forecasts of 8 percent or better.
Gold prices dropped $140 to $1,361 an ounce, a 9 percent fall. It has fallen $203 an ounce over the past two days. Crude oil slid $2.58 to $88.71 in New York trading.
The plunge in commodity prices hit mining and energy stocks. Cliffs Natural Resources lost 8 percent to $17.65. Freeport-McMoRan Copper & Gold fell 8 percent to $29.52. Analysts at Citigroup placed a "sell" rating on the mining giant on the expectation that copper prices will continue sliding.
In other trading, the Standard & Poor's 500 index slumped 26 points to 1,562, a loss of 1.7 percent. Of the 10 industry groups in the S&P 500, materials and energy stocks fared the worst, sliding 3 percent.
The Nasdaq composite fell 67 points, or 2.1 percent, to 3,227.
Among rising stocks, Citigroup rose 2 percent to $45.87, one of the best gains in the S&P 500. The country's third-largest bank reported earnings that beat analysts' estimates thanks to stronger revenue from trading and investment banking.
Sprint Nextel jumped after Dish Network offered $25 billion to buy the company. Dish's bid is aimed at beating an offer from the Japanese phone company SoftBank. Sprint surged 13 percent to $7.01, while Dish fell 6 percent to $35.41.
Thermo Fisher Scientific offered to pay $13.6 billion to buy genetic testing equipment maker Life Technologies. Thermo Fisher agreed to pay $76 in cash for each share of Life Technologies. Life Technologies rose 7 percent $73.05.
In the market for U.S. government bonds, the yield on the 10-year Treasury note dipped to 1.70 percent from 1.72 late Friday. The yield remains near its low point of the year, 1.69 percent, reached April 5 following news that U.S. employers hired far fewer workers than expected last month.
Americans who get paid in cash and own a small business are at high risk of being audited ? especially if they live in wealthy suburbs: the IRS is going after those from which the agency thinks they can get more taxes.
?It?s just a matter of them going where they think the money?s at,? Steve Rosansky, president and CEO of the Newport Beach Chamber of Commerce, told AP. ?I guess if I were running the IRS I?d probably do the same thing.?
The Internal Revenue Service only audits 1 percent of tax returns each year and can yield greater taxes by targeting wealthy small business owners who might have underreported their earnings.? As a result, the IRS is looking closely at small business owners in New Carrollton, Md., College Park, Ga., Beverly Hills, Calif., and Newport Beach, Calif. ? suburbs that are home to wealthy and middle-class Americans, many of which are sole proprietors.
These five metropolitan regions are more likely to host tax cheats than other neighborhoods, according to a study conducted by the National Taxpayer Advocate, an independent office within the IRS. And those who own construction companies or real estate rental firms are considered by the IRS to be most likely to cheat on their taxes.
Despite the outcome of the study, which looked at tax cheat clusters from 2009, the IRS denies that a person?s ZIP code or employment status determines their likelihood for an audit.
?The IRS initiates audits based on information the taxpayer includes ? or doesn?t include ? on a tax return,? the agency told AL.com. ?We don?t base audits on geography. City or state location plays no role in the audit process whatsoever.?
But data collected by the National Taxpayer Advocate did find that audits were more likely to occur in specific regions and target small business owners ? even if the IRS denies using regional information as an auditing factor.
The agency runs all of its tax returns through a program that gives each return a score called the Discriminant Inventory Function (DIF). Higher scores indicate that there are higher chances for the IRS to collect more money from conducting an audit.
?If your return is selected because of a high score under the DIF system, the potential is high that an examination of your return will result in a change to your income tax liability,? states an IRS publication, according to AP.
Sole proprietors, many of whom have cash businesses, need to be particularly careful about reporting large charitable contributions or home-office expenses if they want to avoid an audit.
?If you?re reporting $8,000 of charitable contributions when you?re only making $50,000, that?s a red flag,? Bob Meighan, vice president of TurboTax, told AP. ?Likewise if you?re reporting business or employee expenses that are out of the ordinary for your income range, that would attract the interest of the IRS as well.?
Elizabeth Maresca, a former IRS lawyer and professor at Fordham University, told the newswire that claiming unusually high employment-related expenses is another red flag that could increase a taxpayer?s DIF score.
?I had a case here where the person made about $40,000 and they claimed $25,000 of employment-related expenses,? she said. ?Most people don?t spend $25,000 to earn $40,000. That?s an unusual number.?
The IRS says it conducts audits primarily to minimize the ?tax gap?, which is the difference between what the federal agency is owed and what is actually paid.? The National Taxpayer Advocate study found that this gap is largest among small business owners.
In 2006 ? the most recent year for which the IRS provides an estimate ? the tax gap was $345 billion. The study pointed out 350 neighborhood communities whose residents face higher risks of being audited as the IRS attempts to collect more money, particularly from those it believes are well-off.
Between word that Explorer Editions are being produced, a reveal of spec details and documentation for the Mirror API being published, it's been a busy night for Google Glass announcements. Now, Mountain View has pushed up the hardware's Android companion app, dubbed MyGlass, to Google Play. Sure, you can download it on any device toting Android 4.0.3 or higher, but Page and Co. say, "If you don't have Glass, then downloading this will be a waste of time." Launching the app takes users through a setup process for the eyewear, which the search behemoth has made available on a webpage as well. Google's also posted a "help" directory to give folks unfamiliar with the glasses a tour of the spectacles. Hit the source links below for the app, the setup experience and the newly added overview of the device.
After 11 years of?imprisonment?in?Guantanamo?Bay, Cuba, Samir Naji al Hasan Moqbel?has never gotten his day in court, but thanks to The New York Times op-ed page, he's finally getting his say in public. Moqbel is one of 43 prisoners at the U.S. military's terrorist detention camp who is currently on a hunger strike, and the essay that appears in Monday's paper under his byline is less a plea for his innocence than it is a horrifying tale of what it's like to be kept alive against your will.
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The 35-year-old Yemeni citizen has been living in Guantanamo for more than 11 years, since being arrested in Pakistan in late 2001. Yet, he has never been faced any criminal charges and is no closer to being released now than he was on the day he arrived. It's been more than two months since he stopped eating, and now twice a day, military police and?under-trained?medical staff tie him down and force feed him through tubes. He says he's down to 132 pounds, but that the last time he weighed himself was over a month ago.?
I will never forget the first time they passed the feeding tube up my nose. I can?t describe how painful it is to be force-fed this way. As it was thrust in, it made me feel like throwing up. I wanted to vomit, but I couldn?t. There was agony in my chest, throat and stomach. I had never experienced such pain before. I would not wish this cruel punishment upon anyone.
The hunger strike is spreading through the prison and has occasionally?led to violent clashes between inmates and guards. It may also soon start to take the lives of some of the 166 detainees who are still there. (If Moqbel's account is true, more than one has dropped below 100 pounds.) There have been hunger strikes in previous years that have failed to have much impact, but now that this one has moved beyond dry headlines on the newswires to the "paper of record," perhaps Americans will take notice once again and remember that despite a four-year-old executive order from President Obama, the government still hasn't found a way to shut down the?controversial?jail.